Lecture de Bernard Vargaftig

Le legs de Claude Bernard

The French noun Legs can be translated either as "legacy" or as "bequest". The title of the present volume implies both meanings. The book is, in one sense, an interpretation of the legacy left to posterity by the experimental discoveries and the thoughts of the famous nineteenth-century French physiologist, Claude Bernard. But the word refers also to the bequest that Bernard left to future sch...

Doctor Bernard de Gordon: professor and practitioner

ascribed in the later of its two MSS. to Bartolomeo de Varignana and accepted as such by Dr. Siraisi (cf. also Isis 1977, pp. 33-39). In the list taken from its preface and printed as Appendix 2, the commentator describes Galen's method of dividing up the art of medicine, illustrating it with examples of individual treatises. Since he expressly notes where a tract no longer survives, it is fair...

Claude Bernard, Cahier de Notes 1850–1860

the discovery of antitoxins (von Behring and Kitasato), the standardization of toxins and anti-toxins, the distinction between active and passive immunization (Ehrlich), bacteriolysis (Pfeiffer), haemolysis, agglutination of blood corpuscles as a diagnostic test, the opsonic index, and prophylaxis and treatment of many diseases by vaccines. In certain diseases, for example, cerebro-spinal menin...

Le Centre de Reanimation respiratoire de l'Hopital Claude-Bernard, Paris.

The 2006 Bernard B. Brodie Award Lecture. Cyp2e1.

Bernard B. Brodie's laboratory was the first to examine the mechanisms of drug-induced toxicity at the molecular level. They found that acetaminophen hepatotoxicity was due to the metabolic activation of the drug to a highly reactive toxic metabolite that depleted cellular glutathione and covalently bound to protein. Subsequent studies revealed that activation of acetaminophen to an active meta...